Apraclonidine in the Diagnosis ofHorner Syndrome: Development of Pupillary Adrenergic Supersensitivity after Pharmacologic Induction

Dr. Clark completed his Bachelor of Arts degree in biology at Thiel College and earned a doctorate in microbiology from Case Western Reserve University. He received post-doctoral training at the University of Texas Southwestern Medical Center in the departments of Microbiology (immunology) and Physiology (muscle metabolism) in Dallas. Dr. Clark is a true leader in glaucoma research. He has served as vice president of Discovery Research and as head of Glaucoma Research at Alcon Laboratories. At these posts, Dr. Clark directed a broad range of high-impact glaucoma research that ranged from fundamental studies of trabecular meshwork and optic nerve biology to steroid-induced glaucoma. Initially in parallel with his work at Alcon Laboratories, Dr. Clark has also had a highly productive academic career at the Health Science Center at the University of Northern Texas. More recently, after retiring from Alcon Laboratories, he has become the Director of the Visual Sciences Program at UNT and heads the North Texas Eye Research Institute. In this capacity, Dr. Clark has trained and mentored many leading researchers that have also gone on to make enormous contributions to ophthalmology. Dr. Clark's research has provided major insights into the basic biochemical, cellular and molecular mechanisms involved in glaucoma pathophysiology. He continues to direct a highly innovative research program that includes molecular genetic and proteomic studies of glaucoma using cutting edge technologies including ocular cell culture, ex vivo organ culture, and rodent models of glaucoma. He has published more than 130 peer-reviewed manuscripts, 206 abstracts, authored 10 book chapters, given 68 invited seminars nationally and internationally, and he is an inventor of more than 60 patents. Diaton tonometry in patients with ocular hypertension, glaucoma, and glaucoma drainage devices-A preliminary study for its potential use in keratoprosthesis patients Comparison of Early Changes in the Neuroretina to those in the Brain in Diabetes Background/Purpose: Longstanding diabetes mellitus is associated with neurodegeneration in the retina (specifically in the ganglion cell layer and nerve fiber layer). Recent evidence indicates that longstanding diabetes mellitus is also associated with cognitive decline and cerebral atrophy. The exact cause of this cerebral atrophy is not yet known. This study seeks to determine if there is a correlation between neuronal degeneration in the brain to that in the retina. Given that the retina is an embryologic extension of the brain, it is biologically plausible that this may be the case. If a correlation is found, the retina …